Eating is for nutrition. This study analyzes weight loss, but not nutrition. I would be interested in which diet meant people had no vitamin or mineral deficiencies. Many people who eat low carbohydrate eat few vegetables and fruit because of their carbo content. I have a difficult time believing that is healthy. The extreme, of course, is the Ketogenic diet.

Klein, S., Burke, L.E., Bray, G.A., Blair, S., Allison, D.B., Pi-Sunyer, X., et al. (2004). Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation. Circulation; 110(18): 2952-2967.


When you’re eating to deal with your emotions, like anxiety, stress or unhappiness, you’re likely not reaching for carrot sticks and blueberries, but carbohydrates, processed foods and even alcohol. Those calories eventually add up and, at the same time, you’re avoiding learning how to deal with difficult emotions and situations. It’s pretty much a lose-lose situation.
Have Protein at Every Meal and Snack. Adding a source of lean or low-fat protein to each meal and snack will help keep you feeling full longer so you're less likely to overeat. Try low-fat yogurt, small portion of nuts, peanut butter, eggs, beans, or lean meats. Experts also recommend eating small, frequent meals and snacks (every 3-4 hours), to keep your blood sugar levels steady and to avoid overindulging.
Did bikini season sneak up on you? Is your soon-to-be worn wedding dress still just a touch too tight? Did a last-minute invite for a beach getaway come your way? You're a lucky dog – and a panicked one too because you want to drop pounds, and fast. These 10 diets are likely to help you lose significant weight within a year, according to a panel of experts who reviewed 41 plans for the U.S. News Best Diets rankings. Just remember: Short-term weight loss is markedly different from long-term weight loss, which is more important for your health.

Research shows this intensity combo also makes you faster. In a 2013 study published in the Journal of Applied Physiology, researchers found that when cyclists performed six weeks of 80/20-style training, they more than doubled their power and performance gains, such as lactate threshold, compared to when they spent more time in moderate training zones.
Instead of subjecting yourself to another endless workout, crank up the intensity and you’ll see results faster than you ever thought possible. The results of a study conducted at McMaster University in Ontario reveal that adult male study subjects who exercised intensely for a single minute had equivalent respiratory and metabolic changes to those who worked out at a slower pace for close to an hour, so if you want to burn through that belly fat, say so long to slow and steady.
Chronic migraines were what first inspired Amanda Tagge to start exercising. “I was hoping to find some relief from my headaches and working out did help but I realized that if I really wanted to feel better I needed to revamp my health habits overall and lose weight,” she says. The more she changed, the better her headaches got and she lost 70 pounds in the process which helped her feel even better. Focusing on all the ways her health was improving kept her going even when the scale wasn’t moving.
Work your core. When many people think of core strengthening, they think of stomach crunches. Crunches are helpful for building abdominal muscles, but contrary to popular belief, crunches won't do much to lose the layer of fat stored in your belly, and can actually cause significant damage to the spine.[34] Instead, try a workout routine that strengthens your whole core, like yoga, or try abdominal presses and planking.[35]
But the whole idea of fast weight loss may be the root of the problem. According to a Time expose on the subject: “When people are asked to envision their perfect size, many cite a dream weight loss up to three times as great as what a doctor might recommend.” An improbable and disheartening goal, and one that obscures the truth that losing small amounts of weight — even ten pounds — still has great health benefits.

Fiber is a type of carbohydrate that your body can't digest, and it helps regulate the body's use of sugar as it slowly passes through your digestive system. Increasing your daily fiber intake can result in greater satisfaction after meals, less blood-sugar spiking and crashing, and subsequent reductions in the amount of calories eaten for the rest of the day. When trying to trim belly fat, aim to get at least 25 grams of fiber in your diet each day. Foods that are rich in fiber include pulses, like lentils and beans; apples and pears, with the skin; nuts and seeds; and cruciferous vegetables like broccoli and Brussels sprouts. Try this recipe for Tabbouleh with Chickpeas for a fiber-packed side dish or a one-dish dinner!
The purpose of the Mayo Clinic Diet is to help you lose excess weight and to find a way of eating that you can sustain for a lifetime. It focuses on changing your daily routine by adding and breaking habits that can make a difference in your weight, such as eating more fruits and vegetables, not eating while you watch TV, and moving your body for 30 minutes a day.
Even if you do meet your goal, it's nearly impossible to keep off the weight over the long term: "The amount of restriction required [to maintain that number] will make you so hungry that you’ll eat everything in sight—it’s survival instinct," Dr. Seltzer says. And since calorie restriction gradually slows your metabolism, your body will be less prepared to burn the foods you binge on, he adds. That could mean gaining more pounds than you lost in the first place.
“This is a great way of eating that I highly recommend to many clients, and I even model in my own life,” says Elizabeth Shaw, RDN, who is in private practice in San Diego and is the co-author of Fertility Foods Cookbook. “Since the premise of the diet is designed to help people who have high blood pressure, low-sodium foods are recommended. But considering that most Americans exceed their daily sodium levels anyway, it’s not surprising that dietitians recommend this style of eating for treating many different conditions, such as heart disease and obesity.”
The researchers hypothesize that participants who abstained from animal products dropped significantly more pounds since plant-based foods include loads of filling fiber and slow-to-digest complex carbs. Though more research is needed to confirm these results, the study authors write, "Vegetarian diets appeared to have significant benefits on weight reduction compared to non-vegetarian diets."
Nuts. It’s very easy to eat until the nuts are gone, regardless of how full you are. A tip: According to science, salted nuts are harder to stop eating than unsalted nuts. Salted nuts tempt you to more overeating. Good to know. Another tip: Avoid bringing the entire bag to the couch, preferably choose a small bowl instead. I often eat all the nuts in front of me, whether I’m hungry or not.
When you're at your heaviest, it can be intimidating to step into a gym and begin running or lifting among the spandex-clad. Working out in your own space is also simply easier to schedule—you can lift weights while the baby naps or first thing in the morning without dragging yourself out the door. "I bought an exercise bike so I can work out whenever I want," says Sarah DeArmond, who lost 100 pounds.
Don't get me wrong — exercising at any time is good for you. But evening activity may be particularly beneficial because many people's metabolism slows down toward the end of the day. Thirty minutes of aerobic activity before dinner increases your metabolic rate and may keep it elevated for another two or three hours, even after you've stopped moving. What that means for you: You're less likely to go back for seconds or thirds. Plus, it'll help you relax post meal so you won't be tempted by stress-induced grazing that can rack up calories, quickly.
Although you do want to increase your walking over time, this doesn’t necessarily mean that you have to be working your way up to a more intensive form of cardio like swimming or running. “Moving on to new exercises is not something someone should feel they have to do unless their goals change and a new exercise is needed to support those goals,” says Gagliardi. “Walking alone can be progressed by changing the distance, speed, terrain, and by adding intervals.”
Live It! This phase is a lifelong approach to diet and health. In this phase, you learn more about food choices, portion sizes, menu planning, physical activity, exercise and sticking to healthy habits. You may continue to see a steady weight loss of 1 to 2 pounds (0.5 to 1 kilogram) a week until you reach your goal weight. This phase can also help you maintain your goal weight permanently.
Barley got its hunger-fighting reputation after Swedish researchers found that eating barley or rye kernels for breakfast kept blood sugar on an even keel. That's because the carbs in barley and rye kernels are "low glycemic index," meaning they raise blood sugar more slowly than some other carbohydrate foods. This helps you avoid a spike, and then a drop, in blood sugar, which can leave you feeling famished.

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Actively support your thyroid with food, vitamins and minerals. This small change can make a huge difference to your weight in a fairly short time. It’s smart to have your thyroid checked though many conventional tests come back “normal” even when you may have low thyroid. But you can still add daily thyroid support safely to see if it helps. If you suspect you have a low-thyroid issue, you can get a handle on your weight issues by making small diet changes and supplementing with the right herbs and minerals.
You may think you're vigilant about watching what you eat, but research shows that stolen bites and tastes can rack up a few hundred uncounted calories, which can put on pounds fast. Eating while distracted can cause mindless eating, too. When women who normally watched their portions had lunch in different situations, they ate 15% more (72 additional calories) while listening to a detective story, compared with when they ate alone and free of any distractions, found a study in the American Journal of Clinical Nutrition.

Consider a weight loss program’s overall approach to food. What will you be eating every day? Does the meal plan react poorly with your food allergies or intolerances? Does the program cater to your special dietary needs, for example, if you are vegan or diabetic? If most (or even some) of the foods are not enjoyable to you, within your budget or readily available, you're going to find that plan tough to stick with.


The good news is that if you're struggling with your size, reducing your calorie intake and increasing your activity level have been clinically shown to help you lose weight. The bad news is that there are no shortcuts and no short-term fixes. Fad diets, herbal supplements, "fat-burning" pills, and highly restrictive diets don't work for long, if at all, and some may cause more harm than good.
Try this interval-training trick on the elliptical trainer: Ride for 30 seconds as fast as you can, then immediately reverse your direction and ride for 30 additional seconds just as fast in the opposite direction. Rest 60 seconds, and repeat. The force of stopping your momentum, as well as going from a dead stop to full speed twice in the same interval, will give your fat-burning efforts a massive boost, says Alwyn Cosgrove, C.S.C.S.

Very good article. Many of the people I work with have health issues related to type 2 diabetes so this article gives excellent direction for those struggling to manage their health condition with an appropriate diet that they can sustain. Counting calories is not necessarily the answer. Often times, people cannot understand why they just cannot lose weight or how they became diabetic or what to do about it. Thanks a lot.


“A lot of people think the foundation of a paleo diet is high-fat meat, but I suggest that it’s vegetables,” says Hultin. The concept is to eat only foods — including meat, fish, poultry, eggs, fruits, and vegetables — that would have been available to our Paleolithic ancestors. This means grains, dairy, legumes, added sugar, and salt are all no-no’s.
Whether you've got 5 or 50 pounds to lose, beginning your weight loss journey can be daunting. Instead of tackling it all at once, start by setting small goals for yourself that you know you can achieve. To lose 174 pounds, Annabelle Goetke did exactly that. "I decided to get more active, parking farther away in lots and taking the stairs whenever possible," she says. "I was tired and breathless at first, but I worked up to an hour of run-walk intervals on the treadmill six days a week."
However, if you’re already on medication and think it could be hampering weight loss efforts, speak with your doctor about your options. It may be possible to transition to a more natural option, like a natural form of birth control, coming up with a plan to transition off medication or simply trying an alternative that’s not known to cause weight gain.
●Halt bad eating habits. Before you cave to the crave, hit the pause button, recommends Pamela Peeke, author of the bestseller “The Hunger Fix: The Three Stage Detox and Recovery Plan for Overeating and Food Addiction.” Ask yourself: “Am I hungry? Angry? Anxious? Lonely? Tired?” Get in touch with your emotions and ask, “Am I’m emotional right now? Am I about to knee-jerk into overeating?”

Barley got its hunger-fighting reputation after Swedish researchers found that eating barley or rye kernels for breakfast kept blood sugar on an even keel. That's because the carbs in barley and rye kernels are "low glycemic index," meaning they raise blood sugar more slowly than some other carbohydrate foods. This helps you avoid a spike, and then a drop, in blood sugar, which can leave you feeling famished.


There are a plethora of resources for getting started on, or maintaining, the Atkins Diet. In addition to the official Atkins website, with recipes, many free downloads, and a support community, there are thousands of websites built by low carb devotees with additional tips, recipes and encouragement. The book, New Atkins for a New You (Est. $12), is also a good place to start the low carb journey. It's highly rated by users, who say it's a great guide for making a dietary lifestyle change. Some like that the science of low carb eating is well presented, others say they would prefer a more casual approach and more recipes. Others point out that all of the information in the book is available on the Atkins website, free of charge.
Weight Watchers is a household name for the majority of Americans. Why? Because it works. In fact, the U.S News and World Report named this the best weight-loss diet for 2016 in their annual rankings — and with good reason. The balanced program lets you eat what you want, track your choices via a points system, and build a weight loss support network with fellow Weight Watchers' members.

Proponents of the Paleo diet say it's a much healthier way to eat than the standard American diet, which is often heavy on added sugars and processed foods. Critics say it's too restrictive, banning dairy, wheat and legumes -- food groups that many nutritionists feel should be part of a healthy diet. However, as we noted earlier in this section, veganism and vegetarianism also ban entire food groups and do not come under the same cloud of criticism.
Rounding out the top three for best weight loss programs on the U.S. News and World Report 2016 rankings, the Biggest Loser meal plan uses a pyramid system with fruits and veggies setting the foundation. Simple tenets back the plan: for example, being mindful of portion control, keeping a food diary, and exercising regularly. So, yes, work will be involved, but the plan is sustainable in the long-term and a likely way to shed pounds.

That’s where these tips come in. We talked with eight women over 40—all of whom have lost 40 or more pounds!—about the tools and methods that helped them make lasting healthy changes. And we've got to admit that they’re pretty darn genius! Try incorporating a few into your weight loss plan, and you just might find yourself on the fast track to getting into those skinny jeans. (Looking for even more slim-down secrets? Don’t miss these 6 things you must do to lose weight over 40.)


Cruciferous veggies are one of the healthiest vegetables you can eat, but unfortunately they’re also the ones most likely to cause your tummy to inflate. Thanks to raffinose, a compound that produces extra gas as it breaks down, broccoli, cabbage, cauliflower and the like can seriously increase your waistline. But don’t ditch them forever. Just save them for meals where you can wear loose pants. Here are other surprising foods that cause gas.
"Feeling stressed can wreak havoc on our bodies. It can cause our body to produce the steroid hormone cortisol, which can make you crave sugary foods that provide instant energy and pleasure. Short-term bursts of cortisol are necessary to help us cope with immediate danger, but our body will also release this hormone if we’re feeling stressed or anxious. When our cortisol levels are high for a long amount of time, it can increase the amount of fat you hold in your belly."
Interested in following a more historical approach to eating? The Primal Blueprint is similar to the Paleo diet, which has roots in how our long-ago ancestors supposedly ate. This plan ditches grain, sugars, and processed foods while focusing on clean eating with plenty of protein (both animal- and plant-based), lots of vegetables, fruits, and healthy fats. The Primal Blueprint acknowledges other health factors too, advocating for lots of low-intensity activity, some high-intensity exercise, strength training, and plenty of sleep.

Created in 2003 by cardiologist Arthur Agatston, this low-carb diet features three phases. The first phase is the most restrictive, limiting carbs such as potatoes and rice. Each subsequent phase becomes more lenient, and the diet emphasizes lean protein, unsaturated fats, and low-glycemic carbs such as nonstarchy vegetables. South Beach promotes lasting lifestyle changes, according to the Mayo Clinic. (21)
Having support is very important with weight loss. If everyone can get on board, it will be easier to achieve your goals. Talk to your family (or friends, roommates, etc) before starting your diet and let them know your plan. Explain why you are making this decision and ways they can help you succeed. Even if they do not change with you, that's okay! Go forward with your plan! They may decide to join you once they see you succeed with weight loss.
“There are many diet plans on the market today that promote good health,” says Emily Kyle, RDN, who is in private practice in Rochester, New York. “The key is finding one that does not cause you stress or agony.” Ask yourself questions such as: Would the diet guidelines make you happy? Anxious? Stressed? Are you able to follow them long term? “Factors such as enjoyment, flexibility, and longevity should be strongly considered,” adds Kyle.
This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
And some of these factors can go pretty deep. Albers says that people often don’t realize how dramatically past experiences influence our relationships with ourselves and bodies. For example, having to clean your plate as a child, getting sweet treats to “cheer up” after a bad day at school, or being called “fat” when you were 8 years old all likely have an impact. “Comments about your body or being urged to lose weight by a parent can do emotional damage for the rest of your life,” Albers says. Unless you deal with these issues, “many people spin their wheels and don't know why they feel so stuck,” she says. For this reason, Langer often refers clients to psychologists who specialize in food issues, and she won’t work with those clients on the nutrition side of things until they’ve started to unpack these fundamental emotional factors. Understanding your relationship to food is an important step in trying to change it.

Say cheese! Adding some extra calcium to your diet could be the key to getting that flat stomach you’ve been dreaming about. Over just 12 months, researchers at the University of Tennessee, Knoxville found that obese female study subjects who upped their calcium intake shed 11 pounds of body fat without other major dietary modifications. To keep your calcium choices healthy, try mixing it up between dairy sources, calcium-rich leafy greens, fatty fish, nuts, and seeds.
When you've got a lot of weight to lose, deciding where to begin can be super-overwhelming—but we've got a good place for you to start. We've talked to dozens of women who completely transformed their bodies—we're talking shedding 50-plus pounds—and pulled together a list of the eight simple changes they made that had the biggest impact on the scale. Their tried-and-true tips might be exactly what you need to get on the path to serious results. But don't just take our word for it: These women's results speak for themselves.
Walking puts all of the abdominal muscles to work. Make sure you swing your arms and contract your midsection while you walk, and maintain a brisk pace. Once you get your body accustomed to a daily walk, you'll hate to go a day without it. Walk for at least thirty minutes each time to achieve the aerobic effect, and be sure to drink plenty of water.

Similar to the CICO diet, the Body Reset has gained popularity via social media, and there isn’t any definitive research that suggests the approach is safe and effective. Celebrity trainer Harley Pasternak created the plan, which is essentially a three-phase liquid diet comprised of smoothies and moderate exercise. While U.S. News notes you may lose weight on the diet, it may be tough to stick with, and isn’t safe for people with diabetes and heart disease. (38)

You can’t skimp on sleep. Losing weight for good calls for a total lifestyle change -- and that includes getting more Zs. Missing the recommended seven to nine hours of shut-eye has been linked repeatedly with increased obesity rates. “When you don’t sleep enough, it certainly affects your brain,” explained Dr. Arad. “What we’ve learned is that people who don’t sleep well are making poor choices — eating more unhealthy diets, and they are obviously more fatigued, so they become less physically active.” In fact, people who sleep six hours or fewer per night on average consume about 300 extra calories the following day.


Sometimes, to whip your body into shape, you have to get a little nutty. While nuts are high in fat, it’s that very fat that makes them such powerful weapons in the war against a ballooning belly. In fact, research from Reina Sofia University Hospital reveals that study participants who consumed a diet rich in monounsaturated fats, like those in nuts, over a 28-day period gained less belly fat than their saturated fat-consuming counterparts while improving their insulin sensitivity.
The MIND diet, or Mediterranean-DASH Intervention for Neurodegenerative Delay, is a sort of hybrid between the DASH diet and the Mediterranean diet. It features foods meant to slow the progression or development of Alzheimer’s disease, the most common form of dementia and an incurable neurodegenerative condition that more than 5 million Americans are living with, according to the Alzheimer’s Association. (12) Some research backs up this notion, including a study published in September 2016 in Alzheimer’s Dementia that found a link between following the MIND Diet and a reduced risk of the disease. (13)
Created in 2003 by cardiologist Arthur Agatston, this low-carb diet features three phases. The first phase is the most restrictive, limiting carbs such as potatoes and rice. Each subsequent phase becomes more lenient, and the diet emphasizes lean protein, unsaturated fats, and low-glycemic carbs such as nonstarchy vegetables. South Beach promotes lasting lifestyle changes, according to the Mayo Clinic. (21)
For example, you might not realize just how much you eat when you go out to happy hour with friends. But if you take the split second to take a step back and make yourself aware of that fact, you’re more able to make a healthy decision. “The awareness and then planning and coming up with strategies for what else I can be doing—that might give me the same benefit of eating those comfort foods that make me feel better,” says Gagliardi.
When you restrict your caloric intake, or cut out specific food groups, you do run the risk of having nutritional deficiencies, especially when it comes to micronutrients. Cutting out fatty foods, for example, could have the inadvertent effect of causing your omega-3 fatty acid intake to plummet, which could increase your long-term risk for cardiovascular disease (8).

The most important consideration of any diet is finding one that you can stick with for the long haul. While many diets promise that you'll quickly shed pounds in the beginning, the truth is that reining in your eating will almost always result in quick, initial weight loss regardless of what program you decide to try. The trick is to find a program that -- after that first couple of weeks -- you can adhere to as your weight loss slows to more realistic levels. Experts say that people who make diets a lifestyle rather than just a "diet," while setting a goal of losing a pound or so a week, are more apt to keep the weight off over the long term.
Belly fat is is different from fat elsewhere in your body. The extra weight some people carry around their waists, arms, and love handles isn’t the same — that’s subcutaneous fat, which sits beneath the skin and is relatively harmless, according to Harvard Medical School. The stuff in your belly, visceral fat, lodges deeper down, around your abdominal organs. It's metabolically active tissue that actually functions like a separate organ, releasing substances into the rest of your body that, in excess, can increase your risk of disease.
"Feeling stressed can wreak havoc on our bodies. It can cause our body to produce the steroid hormone cortisol, which can make you crave sugary foods that provide instant energy and pleasure. Short-term bursts of cortisol are necessary to help us cope with immediate danger, but our body will also release this hormone if we’re feeling stressed or anxious. When our cortisol levels are high for a long amount of time, it can increase the amount of fat you hold in your belly."
“Intermittent fasting can be really challenging if you have an ever-changing schedule,” adds Hultin. “If you're traveling and crossing time zones, it could be very difficult to follow. It might be best for people with more stability in their lives.” Intermittent fasting isn’t safe for people with type 2 diabetes, children, pregnant or lactating women, or anyone with a history of an eating disorder.
Rather than “”diet “ consider “change in eating habits “ identify vegetables that u are willing to eat as well as fruits. At meals eat a protein of choice and fill up on fruits and vegetables until u have eaten enough. You may also have one carbohydrate at each meal and drink any drink that is sugar free( seltzer, unsweetened herbal tea with lemon, coffee with cream) eat well and watch the pounds fall off! Gud luck
"Feeling stressed can wreak havoc on our bodies. It can cause our body to produce the steroid hormone cortisol, which can make you crave sugary foods that provide instant energy and pleasure. Short-term bursts of cortisol are necessary to help us cope with immediate danger, but our body will also release this hormone if we’re feeling stressed or anxious. When our cortisol levels are high for a long amount of time, it can increase the amount of fat you hold in your belly."
You do have to track everything you eat, which is easy if you're following a Weight Watchers' recipe or eating a prepackaged food with the points pre-calculated. It gets a bit trickier when you prepare your own recipes as you have to break down the ingredients and do the math -- although that's certainly simpler if all you're doing is, for example, grilling a chicken breast and making a salad. And, under the new "Freestyle" program, that's a meal that could be points-free under the current guidelines, depending upon whether or not the salad is dressed.
Diet.com is lauded far and wide for their individualistic approach to dieting. As most legitimate weight-loss plans for women will testify, a cookie-cutter diet is rarely successful as every body type, lifestyle, and individual is different. Diet.com embraces those differences and tailors its healthy weight-loss plans to fit your specific needs. Here’s how it works:
The South Beach Diet started as a book that was originally published in 2003, The South Beach Diet: The Delicious, Doctor-Designed, Foolproof Plan for Fast and Healthy Weight Loss (Est. $9). The book is still considered to be the best way to get information on the basic diet, but there are also many follow up books and cookbooks to supplement the original, as well as South Beach compliant recipes available around the Internet. The official South Beach Diet website is mostly fee-based.
Gym memberships can be expensive, and some days you just can't make it into the gym. Or maybe, you might not feel comfortable in a gym quite yet. At the start of her weight loss journey, Suheily Rodriguez says he was too embarrassed to go to a gym. "So I built a home one," she says, "where I exercised an hour a day, six days a week." She credits this to her 96-pound weight loss.
It’s impossible to target belly fat specifically when you diet. But losing weight overall will help shrink your waistline; more importantly, it will help reduce the dangerous layer of visceral fat, a type of fat within the abdominal cavity that you can’t see but that heightens health risks, says Kerry Stewart, Ed.D., director of Clinical and Research Physiology at Johns Hopkins.
Mason, A. E., Epel, E. S., Aschbacher, K., Lustig, R. H., Acree, M., Kristeller, J., … Daubenmier, J. (2016, May 1). Reduced reward-driven eating accounts for the impact of a mindfulness-based diet and exercise intervention on weight loss: Data from the SHINE randomized controlled trial. Appetite , 100, 86–93. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799744/
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