So what can we do with all this knowledge? Tempting as it is to get discouraged, we can actually find it encouraging. Biology is not destiny, after all. “Lifestyle choices are immensely powerful,” Peeke says. And on the heels of any tidal wave of new research is sure to come a trickle of weight-loss advice that can be more customized and more effective to help men and women with their weight-loss obstacles, no matter what they are.

Whether you've got 5 or 50 pounds to lose, beginning your weight loss journey can be daunting. Instead of tackling it all at once, start by setting small goals for yourself that you know you can achieve. To lose 174 pounds, Annabelle Goetke did exactly that. "I decided to get more active, parking farther away in lots and taking the stairs whenever possible," she says. "I was tired and breathless at first, but I worked up to an hour of run-walk intervals on the treadmill six days a week."

Sure, you can lose weight quickly. There are plenty of fad diets that work to shed pounds rapidly -- while leaving you feeling hungry and deprived. But what good is losing weight only to regain it? To keep pounds off permanently, it's best to lose weight slowly. And many experts say you can do that without going on a "diet." Instead, the key is making simple tweaks to your lifestyle.
×