Both men and women are prone to an all-or-nothing approach to weight loss (for example, after a binge, figuring, “Well, I blew it. I might as well go all out!”). But Sass says she sees more women take extreme measures to get back on track, with tactics such as juice cleanses, skipping meals or extreme dieting — not the most sustainable methods. “Most but not all men tend to just try to get back on track with the original plan, or build in a little more exercise,” she says. That is, they take a more balanced approach to getting back on track, just trying to regroup and get back on the diet, or build in a little more exercise.

‘Do it for a couple of minutes in bed and you’ll actually be able to wind down and fall asleep more easily. But it’s a skill, so it requires a commitment to practice it, as with anything. Think of it a bit like dating – the first time you do it it’s terrible, it’s uncomfortable, nobody knows what they’re doing, but the more dates you go on the better it gets.


And at the gym, that difference just gets exacerbated. Women, worried about bulking up, tend to lift lighter weights and focus more on cardiovascular fitness, while men tend to gravitate toward the kind of heavy lifting that boosts muscle composition and metabolic rate, says Jim White, a Virginia Beach-based nutrition expert and certified personal trainer.

And while the weight room can be intimidating for women, pumping iron is key to getting a toned and fit physique. Don’t worry, lifting heavy weights won’t make you bulky — you just don’t have the testosterone to build the size of a man. Lifting will improve your posture, make your arms, core and lower body more shapely and boost your metabolism by building muscle. Resistance training also helps you hold onto muscle that you naturally lose as you age.
Intraday Data provided by SIX Financial Information and subject to terms of use. Historical and current end-of-day data provided by SIX Financial Information. All quotes are in local exchange time. Real-time last sale data for U.S. stock quotes reflect trades reported through Nasdaq only. Intraday data delayed at least 15 minutes or per exchange requirements.
Eat more protein. Protein is required by the body to repair damaged cells and plays a vital role in growth and development.[3] But it can also play a role in weight loss. Diets high in protein tend to make people feel fuller, and when paired with a reduction in carbohydrate intake these diets can help with weight loss.[4] However, it's important to remember that not all sources of protein are good for you: red meat and full-fat dairy products, though high in protein, can also increase the risk of heart disease.[5] Good sources of protein include:[6]

How much fiber should I eat per day? Most Americans eat less fiber than the USDA daily recommendations suggest. This article looks at the guidelines for fiber intake in men, women, and children. We also talk about how fiber can help with weight loss, and discuss how much fiber is too much. Learn about good sources of dietary fiber and a handy meal plan. Read now


And at the gym, that difference just gets exacerbated. Women, worried about bulking up, tend to lift lighter weights and focus more on cardiovascular fitness, while men tend to gravitate toward the kind of heavy lifting that boosts muscle composition and metabolic rate, says Jim White, a Virginia Beach-based nutrition expert and certified personal trainer.
Food preferences: Think about whether the foods on a given diet are things that you generally enjoy. If you hate eating greens, you won’t like a diet filled with salads; but if you have a sweet tooth, a diet that substitutes milkshakes for meals might be more your speed. Consider a diet's overall approach to food and ask yourself, realistically, if you can eat the foods on this plan more or less for the rest of your life? And will you enjoy the foods on a given diet plan, or if it will feel like a “diet” food that you won’t be able to stick with long-term?
Have you ever decided to skip a meal to cut back on your daily calorie count? Despite saving a few calories in the moment, this strategy almost always backfires. When you skip breakfast, or any meal, you'll begin to experience excessive hunger that can lead to craving unhealthy foods—and lots of them. You may also eat faster than you normally do after skipping a meal, causing you to miss the warning signs that you're full and resulting in overeating.
Nontraditional pastas, like those made from beans, rice, and soy products, have become increasingly popular as a healthier option for pasta fans. However, that doesn’t mean you can load up on veggie noodles with no consequences. “We would be wise to remember that these pastas, while more nutrient dense than traditional white pasta, still have calories and carbohydrates,” says Monica Auslander Moreno, MS, RD, LD/N, nutrition consultant for RSP Nutrition. “Portions are still set at a measly 1/2 cup cooked; most of us do 2-3 cups of cooked pasta at a time. Try going ‘half and half’ with pasta alternatives and a vegetable pasta substitute.” Check out these weight-loss breakthroughs doctors wish you knew.
Stress skyrockets your levels of cortisol, often called “the belly fat” hormone because it signals to the body to store fat around your waist. Add the daily stressors of living our modern lifestyle and you can see how cortisol can be constantly coursing through your veins. This perma-stress mode isn’t good for a lot of healthy reasons, your tummy being just one of them, so it’s important to take time every day to de-stress. Yoga, meditation, walking, journaling, doing a hands-on hobby, or playing a musical instrument are all great time-tested methods. (Hint: Know what isn’t? Watching television. The boob tube actually increases your levels of cortisol!)
If you’re having trouble getting to bed, these 20 sleep strategies can help. To help stick to these strategies, consider these sleep tips your weight loss tips as well. Shutting off electronics an hour before bedtime, limiting caffeine intake in the afternoons, avoiding simple carbs in the evenings and journaling can all help you unwind so you get enough rest. You can also consider natural sleep aids to boost your ability to fall asleep and sleep soundly.
Want to blow away your belly without logging months of mind-numbing hours on the treadmill? High Intensity Interval Training (HIIT) will kickstart your metabolism like no other workout, burning more than twice the calories as a lighter and longer session, according to a study from Southern Illinois University. And the total amount of time you need to dedicate to HIIT: 20 minutes. It really is the least time exercising for the biggest results.
Consequently, researchers have widely discredited the hCG diet, which involves using hCG injections, pellets, sprays, or drops, and consuming  as few as 500 calories daily. The diet is problematic not only because there’s a lack of research on hCG supplements, but also because the calorie requirement is dangerously low, potentially leading to nutrient deficiencies, fatigue, hormone imbalances, blood clots, and other issues. Thus, most experts agree the hCG diet is not safe for anyone, the Mayo Clinic notes. (35)
You know the drill: Replace refined, overly processed foods with more natural, whole foods. Sure, all foods fit, but they don’t all fit equally. Here’s why: Every time you eat, your metabolism increases as your body works to process your meal. Studies that compare the metabolic boost of calorie-matched whole foods to processed ones find that your body can burn up to 50 percent more calories after a meal made with more real food ingredients compared to a similar meal made with more processed fare. The fact is, your body has to work harder to break down whole foods in order to grab the raw materials it needs so if you exist on a lot of packaged foods and fast foods (think: chips, donuts and drive-thru fare), it’s going to be tougher to lose weight and keep those pounds from coming back.

While it’s often assumed that bread is off-limits when you’re trying to lose belly fat, the right bread may actually expedite the process. Switching to sprouted bread can help out carb-lovers eager to get their fix without going up a belt size, thanks to the inulin content of sprouted grains. The results of a study published in Nutrition & Metabolism reveal that found that pre-diabetic study subjects whose diets were supplemented with inulin shaved off more belly fat and total weight than those whose meal plans didn’t pack this healthy prebiotic fiber.
Instant oatmeal may be a lot quicker to make than traditional oats, but what you gain in convenience you lose in nutritional value. Many of the oatmeal’s healthy properties are stripped away in processing, explains Stephanie Lincoln, an eating psychology specialist and the founder and CEO of Fire Team Whiskey Military Health and Fitness. Plus, sugar is added during manufacturing. These two factors turn instant oatmeal into a high glycemic index food, making you feel hungry even after you’ve just eaten. One study found that people who ate instant oatmeal for breakfast instead of eggs were found to eat 81 percent more food during the day. And one thing you don’t want when you’re trying to lose weight is the munchies. Next, don’t miss these 42 easy tricks for losing weight fast.
One of the biggest mistakes women make when trying to figure out how to lose belly fat: too many crunches, too little cardio. No matter how toned your abs are, your belly won't look flat until you get rid of the layer of fat on top of them, says Jessica Smith, a certified personal trainer and star of fitness DVDs. For that, you need to rev your calorie burn. Interval training, in which you alternate high-intensity bursts of activity with easier bouts, has been shown to zap more belly fat than steady-paced moderate workouts.
No, we’re not telling you that you need a tummy tuck (although that would flatten your belly, we suppose). Rather, there are several common health conditions that can make your belly bulge and until you fix the anatomical issues underneath, nothing else can flatten it out. For instance, many women have a diastisis recti, or separation of the abdominal muscles, after pregnancy. In about 25 percent of these women, the muscles never quite come back together, leading to a permanent protrusion. Similarly, a hernia (congenital or from an injury) can also cause your belly to stick out. Both conditions can be resolved surgically.
Cruciferous veggies are one of the healthiest vegetables you can eat, but unfortunately they’re also the ones most likely to cause your tummy to inflate. Thanks to raffinose, a compound that produces extra gas as it breaks down, broccoli, cabbage, cauliflower and the like can seriously increase your waistline. But don’t ditch them forever. Just save them for meals where you can wear loose pants. Here are other surprising foods that cause gas.
Having a healthy option at your fingertips when you’re starving can make all the difference between sticking to your goals and giving in to temptation. “I keep little containers of hummus and carrots, pickles, nuts and dried apricots, salsa and rice crackers, and other healthy combos in the front of my fridge and pantry so they are literally the first thing I see when I open the door,” says Lita Moreno. “I don’t even give myself a choice to cheat.” This one little change has helped her drop almost 80 pounds.
Visceral fat, commonly known as belly fat, is the layer of fat below the muscles of your abdomen. Due to its crucial location surrounding many of your vital organs, belly fat supplies a constant source of energy but also exposes the body to harmful toxins and hormones. When you have too many fat cells or your fat cells get too large, they can overproduce toxins that increase your risk for chronic inflammation, diabetes, heart disease and cancer. This is why belly fat can be more dangerous than subcutaneous fat—or the outer layer of fat that you can pinch with your fingers. That said, the reason you're having trouble buttoning your pants may not be visceral fat: what we're calling "belly fat" these days could be bloating or water retention rather than a fat buildup. Read on for steps you can take to beat the bulge.

Rains, T. M., Leidy, H. J., Sanoshy, K. D., Lawless, A. L., & Maki, K. C. (2015, February 10). A randomized, controlled, crossover trial to assess the acute appetitive and metabolic effects of sausage and egg-based convenience breakfast meals in overweight premenopausal women. Nutrition Journal, 14, 17. Retrieved from https://nutritionj.biomedcentral.com/articles/10.1186/s12937-015-0002-7
Fiber is a type of carbohydrate that your body can't digest, and it helps regulate the body's use of sugar as it slowly passes through your digestive system. Increasing your daily fiber intake can result in greater satisfaction after meals, less blood-sugar spiking and crashing, and subsequent reductions in the amount of calories eaten for the rest of the day. When trying to trim belly fat, aim to get at least 25 grams of fiber in your diet each day. Foods that are rich in fiber include pulses, like lentils and beans; apples and pears, with the skin; nuts and seeds; and cruciferous vegetables like broccoli and Brussels sprouts. Try this recipe for Tabbouleh with Chickpeas for a fiber-packed side dish or a one-dish dinner!
If muscling up is key to shedding timber, you might as well do so efficiently. Rehash your recovery period by introducing short rest intervals within your sets. Switching your 120-second rest between sets to a 60-second intra-set break brings greater strength gains and increased power output, according to a study published in the Journal of Strength and Conditioning Research.

Fibrous foods are as close to a “miracle belly flattening pill” as we have. Fruits, vegetables, and whole grains, particularly those high in soluble fiber, have been proven to reduce fat around your midsection. In addition, these foods fill you up so you eat less, flattening your stomach over time. Try one of these 5 easy ways to turn off your fat genes and keep the weight off for good.


While the American College of Sports Medicine warns that women who eat less than 1,300 calories a day and men who eat less than 1,800 risk slowing down their metabolism over time. But a rev-up stage that only lasts two weeks is approved by doctors and isn’t as difficult as it seems. Our tester found the Mayo Clinic day pretty satisfying, and still had enough energy to hit the gym.

Intraday Data provided by SIX Financial Information and subject to terms of use. Historical and current end-of-day data provided by SIX Financial Information. All quotes are in local exchange time. Real-time last sale data for U.S. stock quotes reflect trades reported through Nasdaq only. Intraday data delayed at least 15 minutes or per exchange requirements.

‘Lastly, if your nutrition is on point but you still have excess tummy fat, then you need to look at your training. There’s a real craze for high-intensity workouts and really pushing yourself at the moment, but training is a stress on the body, and if you’re not giving it the tools to manage that stress and recover from it, then it can lead things like excess belly fat.
Known as the carb-hating diet, the South Beach diet is a weight-loss food plan centered around low-carbohydrate meals. It’s important to note that the South Beach Diet doesn’t forbid carbohydrates, unlike many fad diets out there, instead, this healthy weight-loss system understands the intrinsic benefits of healthy carbs and builds them into your meal plans to maximize those strengths for optimal health and weight loss.
Sometimes, to whip your body into shape, you have to get a little nutty. While nuts are high in fat, it’s that very fat that makes them such powerful weapons in the war against a ballooning belly. In fact, research from Reina Sofia University Hospital reveals that study participants who consumed a diet rich in monounsaturated fats, like those in nuts, over a 28-day period gained less belly fat than their saturated fat-consuming counterparts while improving their insulin sensitivity.
While it will help, it’s not going to eliminate your sleep deprivation. That apart, doing this will throw off your natural sleep-wake cycle so it could end up doing more harm than good. Not only can the right food aid sleep, it works the other way too — better sleep promotes weight loss. Lack of sleep, however, has been found to stimulate production of hunger hormone ghrelin, which makes us overeat.
Ease into running. You might get discouraged if you attempt a jog without building up that type of strength—and this could put a damper on your motivation. "I started walking, and before long, I was running," says Cipriana Cuevas, who lost 60 pounds and eventually completed a half marathon. "Getting lighter made running easier, and, in turn, more fun."
First, as women near midlife, their ratio of fat to body weight increases rapidly. Second, many women see that new fat mostly around their bellies. This is “visceral fat” and it can change the entire shape of your midsection. Visceral fat cells are like miniature endocrine organs that are especially active, setting off inflammation and increasing insulin resistance. Third, visceral fat gets a huge boost from lifestyle issues like depression and stress, poor sleep, smoking (proven to increase belly fat ), irritability, and drinking fructose-sweetened beverages (leads to more visceral fat and decreases insulin sensitivity).
Many diet plans rely on meal-replacement shakes, bars or other snack type foods, while others rely on frozen entrees as a major part of your diet, like Medifast and Nutrisystem. Ask yourself if you want the bulk of your diet relying on prepackaged snacks, shakes or frozen meals, or if you prefer the flexibility of cooking your own meals or eating out frequently.
Known as the carb-hating diet, the South Beach diet is a weight-loss food plan centered around low-carbohydrate meals. It’s important to note that the South Beach Diet doesn’t forbid carbohydrates, unlike many fad diets out there, instead, this healthy weight-loss system understands the intrinsic benefits of healthy carbs and builds them into your meal plans to maximize those strengths for optimal health and weight loss.

FitDay combines professional support from dietitians, with a variety of useful tools to help you lose weight and keep it off. Whilst it’s not the cheapest option around, the expert advice and support are great for keeping you motivated and tracking accurate data to help improve your weight loss and attain your personal goals. Information is key, and the online tools help to keep...
It's no surprise that Dr. Dean Ornish's program is such a powerful tool for weight loss, considering its easy adaptability as a lasting lifestyle. The diet is mostly plant-based, keeps sodium intake in moderation, and limits coffee to a cup a day (two cups decaf) — so if you're looking to lose weight while keeping your java flow, you may want to consider another plan.
If you've been trying to eat healthy for a long time, you know how quickly you get sick of chicken breasts and broccoli. Break out of your diet rut with the Middle Eastern diet. It's based on the same principles as the Mediterranean diet but with more of an emphasis on plant-based foods and a different flavor profile. With all the tasty and healthy spices, you'll never get bored of making dinner and you'll get all the same heart-healthy benefits as its geographical cousin's diet.

Little treats keep you from feeling deprived, so every day, allow yourself a bit of something you love (aim for 150 calories each). This kind of moderation is the difference between a "diet" and a lifestyle you can stick with forever. For salon owner Caitlin Gallagher, who lost 125 pounds, that meant replacing her nightly bowl of ice cream with a square of chocolate; social worker Brittany Hicks, who lost 100 pounds, started baking mini versions of her favorite pies.
In 2008 between US$33 billion and $55 billion was spent annually in the US on weight-loss products and services, including medical procedures and pharmaceuticals, with weight-loss centers taking between 6 and 12 percent of total annual expenditure. Over $1.6 billion a year was spent on weight-loss supplements. About 70 percent of Americans' dieting attempts are of a self-help nature.[24][25]
“I learned how to cook from scratch and experiment with flavors. The biggest change my husband Mark and I made was planning our meals for the week on Sundays. We also rely on food optimizing—using vegetables to bulk up our meals but still keep them low-calorie. It helped me lose 52 pounds and 8 dress sizes, while Mark lost 110 pounds.” —Amanda Gibbon, 46
“It can take 12 minutes or longer for the signal that you’ve started to eat to make its way to your brain,” says Mark S. Gold, M.D., of the McKnight Brain Institute at the University of Florida. Quick tips: Sip some water between every bite of food you eat, or at least eat more meals with friends or family members. You’ll be more likely to talk and therefore to eat more slowly.
Fermented foods: These enhance the function of good bacteria while inhibiting the growth of bad bacteria. Sauerkraut, kimchi, kefir, yogurt, tempeh, and miso all contain good amounts of probiotics, which help to increase good bacteria. Researchers have studied kimchi widely, and study results suggest that it has anti-obesity effects. Similarly, studies have shown that kefir may help to promote weight loss in overweight women.
With this eating style, you’re looking at a lot of menu planning and preparation. A review published in August 2017 in Nutrients suggests the diet could lead to weight loss, but the Academy of Nutrition and Dietetics warns the plan could also cause certain nutrient deficiencies, such as in calcium and vitamin D. (3,4) And, therefore, according to an article published in the January–February 2016 issue of the Royal Australian College of General Practitioners, anyone at risk for osteoporosis should avoid it. (5)
Fiber is an indigestible carbohydrate from plant-based foods like bran flakes and strawberries that absorbs water and helps us eliminate waste as it travels through the digestive system. According to a review published in Journal of American College of Nutrition, fiber may increase satiety to keep you fuller longer and dietary fiber intake is associated with lower body weight. Mayo Clinic recommends that women should aim for at least 21 to 25 g of fiber a day, while men should aim for 30 to 38 g a day.
If you’re having trouble getting to bed, these 20 sleep strategies can help. To help stick to these strategies, consider these sleep tips your weight loss tips as well. Shutting off electronics an hour before bedtime, limiting caffeine intake in the afternoons, avoiding simple carbs in the evenings and journaling can all help you unwind so you get enough rest. You can also consider natural sleep aids to boost your ability to fall asleep and sleep soundly.
Work indulgence foods into your calorie plan. If you do want to have something that is a little higher in calories, then make sure that you work it into your overall calorie goal for the day. For example, if you are following an 1,800 calorie plan, and you want to have a brownie that is 300 calories, then you would only have 1,500 calories left for the day.
Eat more protein. Protein is required by the body to repair damaged cells and plays a vital role in growth and development.[3] But it can also play a role in weight loss. Diets high in protein tend to make people feel fuller, and when paired with a reduction in carbohydrate intake these diets can help with weight loss.[4] However, it's important to remember that not all sources of protein are good for you: red meat and full-fat dairy products, though high in protein, can also increase the risk of heart disease.[5] Good sources of protein include:[6]

Add a cup of low-fat milk, a part-skim mozzarella stick, or a half cup of low-sodium cottage cheese to breakfast, and you may have a belly-busting win. While lots of research links calcium with lower body weights, results from a 2014 study suggest that calcium-containing foods may reduce waist circumference in those genetically predisposed to carrying weight in their midsection.

Klein, S., Burke, L.E., Bray, G.A., Blair, S., Allison, D.B., Pi-Sunyer, X., et al. (2004). Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation. Circulation; 110(18): 2952-2967.
There's a pretty dizzying amount of research backing up this regime as a solid option to enhance your health, lower cholesterol, and encourage healthy, lasting weight loss. DASH (the acronym stands for Dietary Approaches to Stop Hypertension) has you loading up on fruits, vegetables, and whole grains (surprise!) and removing foods high in saturated fat from your diet. Research also shows that this diet may even ward off the onset of type 2 diabetes.
Similar to the CICO diet, the Body Reset has gained popularity via social media, and there isn’t any definitive research that suggests the approach is safe and effective. Celebrity trainer Harley Pasternak created the plan, which is essentially a three-phase liquid diet comprised of smoothies and moderate exercise. While U.S. News notes you may lose weight on the diet, it may be tough to stick with, and isn’t safe for people with diabetes and heart disease. (38)
“I started my 78-pound weight-loss journey by tracking everything I ate with the Lose It! app. I track right after I finish because if I wait until later, I don’t always remember. Sometimes I’ll even record before I eat, so I know if I have enough calories for the day. That, paired with daily weigh-ins helps to keep me accountable.” —Kari Hammond, 42
"Your body needs a healthy balance of exercise and rest. Doing too much prevents the body from shifting excess fat. Exercising without rest can impact our levels of the steroid hormone cortisol and cause an increase of stubborn fat stored in the belly. Not allowing your body to recover can increase the risk of injury too, so make sure you factor in rest days to your plan."

Satisfying your sweet tooth doesn't require a refined sugar-packed snack. The key is retraining your taste buds to recognize naturally sweet foods, like fruit. "To curb my hankering for treats, I eat mangoes," says Tamyala Ezell, who lost 105 pounds by making over her eating habits and working out three times a week. "They have a natural sweetness that does the trick. Plus, they're low in calories and high in fiber." Another example? "I top berries, nectarines, and cherries with homemade whipped cream, nuts, and dark chocolate," says Goetke.


‘Lastly, if your nutrition is on point but you still have excess tummy fat, then you need to look at your training. There’s a real craze for high-intensity workouts and really pushing yourself at the moment, but training is a stress on the body, and if you’re not giving it the tools to manage that stress and recover from it, then it can lead things like excess belly fat.
When you eat foods that are low- or no-fat, other ingredients are added in so that the food tastes like its full-fat counterpart. Those extra ingredients don’t add in the nutrients that have been stripped away, however, so you end up craving more because, despite the fact that you just ate, your body is still lacking in the vital nutrients it needs. You end up eating more calories than you would have if you’d just eaten the full-fat product.
Sure, you certainly need to drink plenty of water to help expedite the process of ridding your body of excess sodium, you can (and should!) also consume high-water content foods. Reach for cucumbers, tomatoes, watermelon, asparagus, grapes, celery, artichokes, pineapple, and cranberries — all of which contain diuretic properties that will also help you stay full due to their higher fiber content.
Because the diet isn’t as restrictive as a traditional vegan or vegetarian diet, it may be simpler to stick with — hence its No. 2 ranking in U.S. News & World Report’s Easiest Diets to Follow category. Because you’ll be eating meat some of the time, you may also be at a lower risk of the aforementioned nutrient deficiencies that vegetarians and vegans may face.
Without alcohol, they’re less fattening, right? Yes and no. It’s true that alcohol adds calories, but so do the ingredients you’re swapping in. Virgin margaritas, pina coladas, and daiquiris are made with fruit juices and sometimes syrups, which have loads of calories and sugars. Instead, Amidor recommends sticking with alcohol—in 5 ounces of wine or a 12-ounce light beer. Here are the weight-loss motivation techniques 22 real people used to lose weight.
Drink water. Contrary to another popular misconception there is no specific amount of water you should ingest. Everyone has different needs based on genetics, activity level, the environment they live in etc. The key is to drink water until your pee looks like lemonade. If it looks like apple juice keep drinking. The reason this helps flatten your tummy is two fold: hydration can boost fat metabolism by up to 3% and drinking water flushes out excess bloat and water weight you might be holding on to.

While you may be tempted to eat as few calories as possible to lose weight more quickly, as mentioned above, it’s important that you don’t cut more than 1,000 calories from your daily diet or eat fewer than 1,200 calories a day — even if that means your energy deficit is smaller than 1,000 calories. Eat too little and you’ll slow down your metabolism and put yourself on track to regain the weight — often with a few extra pounds.
Mason, A. E., Epel, E. S., Aschbacher, K., Lustig, R. H., Acree, M., Kristeller, J., … Daubenmier, J. (2016, May 1). Reduced reward-driven eating accounts for the impact of a mindfulness-based diet and exercise intervention on weight loss: Data from the SHINE randomized controlled trial. Appetite , 100, 86–93. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799744/
×